Inflammasome-independent functions of AIM2

J Exp Med. 2021 May 3;218(5):e20210273. doi: 10.1084/jem.20210273.

Abstract

AIM2 is widely known for its role as a cytosolic dsDNA receptor that activates the inflammasome. In this issue of JEM, Ma et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201796) describe an inflammasome-independent function of AIM2 in microglia that restrains neuroinflammation via a novel crosstalk between AIM2 and cGAS signaling.

Publication types

  • Comment

MeSH terms

  • DNA
  • DNA-Binding Proteins* / metabolism
  • Inflammasomes*
  • Nucleotidyltransferases
  • Signal Transduction

Substances

  • DNA-Binding Proteins
  • Inflammasomes
  • DNA
  • Nucleotidyltransferases