GSEAplot: A Package for Customizing Gene Set Enrichment Analysis in R

J Comput Biol. 2021 Jun;28(6):629-631. doi: 10.1089/cmb.2020.0426. Epub 2021 Apr 16.

Abstract

Gene Set Enrichment Analysis (GSEA) is used to identify differentially expressed gene sets that are enriched for annotated biological functions. The existing GSEA R code is not in the form of a flexible package with analysis and plotting customization options, and the results produced are not generated in the form of R objects. In this study, we introduce the GSEAplot R package with novel functionality for saving relevant information from the analysis to the current R workspace, and we introduce the ability to customize plots and databases. The GSEAplot package provides a novel utility that facilitates the implementation of GSEA R-based in genomics analysis pipelines.

Keywords: R package; functional enrichment analysis; gene set analysis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computational Biology / methods*
  • Databases, Genetic
  • Gene Expression Profiling / methods*
  • Humans
  • Software*