Seeing the forest for the trees-single-cell atlases link CD8+ T cells and macrophages to disease progression and treatment response in kidney cancer

Mei Yee Koh; Nicolas Sayegh; Neeraj Agarwal

doi:10.1016/j.ccell.2021.03.008

Seeing the forest for the trees-single-cell atlases link CD8⁺ T cells and macrophages to disease progression and treatment response in kidney cancer

Cancer Cell. 2021 May 10;39(5):594-596. doi: 10.1016/j.ccell.2021.03.008. Epub 2021 Apr 15.

Authors

Mei Yee Koh¹, Nicolas Sayegh², Neeraj Agarwal³

Affiliations

¹ Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112; Department of Pharmacology and Toxicology, University of Utah, 30S 2000E, Salt Lake City, UT 84112.
² Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112.
³ Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112. Electronic address: [email protected].

PMID: 33861995
DOI: 10.1016/j.ccell.2021.03.008

Abstract

Intra- and interpatient heterogeneity of clear cell renal cell carcinoma (ccRCC) confounds the search for therapies associated with durable tumor responses and predictive biomarkers. Here, Braun et. al., Krishna et.al, and Bi et.al. use single-cell mRNA sequencing to characterize progressive immune dysfunction associated with ccRCC progression and resistance to immunotherapies.

Keywords: CD8(+) T cells; biomarkers; immune checkpoint blockade; kidney cancer; macrophage; single-cell RNA sequencing.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes
Carcinoma, Renal Cell* / genetics
Carcinoma, Renal Cell* / therapy
Disease Progression
Humans
Kidney Neoplasms* / genetics
Kidney Neoplasms* / therapy
Macrophages

Grants and funding

R01 CA217905/CA/NCI NIH HHS/United States