Altered Thalamocortical Connectivity in 6-Week-Old Infants at High Familial Risk for Autism Spectrum Disorder

Cereb Cortex. 2021 Jul 29;31(9):4191-4205. doi: 10.1093/cercor/bhab078.

Abstract

Converging evidence from neuroimaging studies has revealed altered connectivity in cortical-subcortical networks in youth and adults with autism spectrum disorder (ASD). Comparatively little is known about the development of cortical-subcortical connectivity in infancy, before the emergence of overt ASD symptomatology. Here, we examined early functional and structural connectivity of thalamocortical networks in infants at high familial risk for ASD (HR) and low-risk controls (LR). Resting-state functional connectivity and diffusion tensor imaging data were acquired in 52 6-week-old infants. Functional connectivity was examined between 6 cortical seeds-prefrontal, motor, somatosensory, temporal, parietal, and occipital regions-and bilateral thalamus. We found significant thalamic-prefrontal underconnectivity, as well as thalamic-occipital and thalamic-motor overconnectivity in HR infants, relative to LR infants. Subsequent structural connectivity analyses also revealed atypical white matter integrity in thalamic-occipital tracts in HR infants, compared with LR infants. Notably, aberrant connectivity indices at 6 weeks predicted atypical social development between 9 and 36 months of age, as assessed with eye-tracking and diagnostic measures. These findings indicate that thalamocortical connectivity is disrupted at both the functional and structural level in HR infants as early as 6 weeks of age, providing a possible early marker of risk for ASD.

Keywords: ASD; functional connectivity; high-risk infants; structural connectivity; thalamus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autism Spectrum Disorder / diagnostic imaging*
  • Autism Spectrum Disorder / genetics
  • Autism Spectrum Disorder / psychology
  • Biomarkers
  • Cerebral Cortex / diagnostic imaging
  • Child Behavior Disorders / diagnostic imaging
  • Child Behavior Disorders / genetics
  • Child Behavior Disorders / psychology
  • Child, Preschool
  • Diffusion Tensor Imaging
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neural Pathways / diagnostic imaging*
  • Psychomotor Performance
  • Risk Assessment
  • Social Behavior
  • Sociodemographic Factors
  • Thalamus / diagnostic imaging*

Substances

  • Biomarkers