Definitions of Bias in Clinical Research

Geoffrey Warden

doi:10.1007/978-1-0716-1138-8_3

Definitions of Bias in Clinical Research

Methods Mol Biol. 2021:2249:35-52. doi: 10.1007/978-1-0716-1138-8_3.

Author

Geoffrey Warden¹

Affiliation

¹ Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada. [email protected].

PMID: 33871837
DOI: 10.1007/978-1-0716-1138-8_3

Abstract

In this chapter, a catalog of the various types of bias that can affect the validity of clinical epidemiologic studies is presented. The biases are classified by stage of research: literature review and publication, design of the study and selection of subjects, execution of the intervention, measurement of exposures and outcomes, data analysis , and interpretation and publication. Definitions are provided for each type of bias listed.

Keywords: Bias; Classification; Definition; Stage of research.

MeSH terms

Bias*
Confounding Factors, Epidemiologic*
Epidemiologic Studies
Humans
Outcome and Process Assessment, Health Care
Patient Selection
Research Design*
Selection Bias