Abstract
We developed NIR-light-responsive macrocyclic cationic gemini amphiphiles, one of which displayed various favorable properties of lipids. The NIR-light-mediated cleavage of the strained dioxacycloundecine ring led to the conversion of the spherical to a nanotubular self-assembly in the aqueous medium. This photo-mediated transformation from the spherical to nanotubular self-assembly resulted in the release of encapsulated hydrophobic anticancer drug molecule doxorubicin (Dox) in a controlled manner. The potent cationic gemini amphiphile also displayed lower cytotoxicity and efficient NIR-light-mediated Dox release efficacy to cancerous cells.
MeSH terms
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / pharmacology*
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Calcitriol / analogs & derivatives
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Calcitriol / chemistry
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Cations
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Doxorubicin / chemistry
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Doxorubicin / pharmacology*
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Drug Carriers / chemistry
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Drug Screening Assays, Antitumor
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Humans
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Macrocyclic Compounds / chemistry
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Molecular Structure
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Photochemical Processes
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Surface-Active Agents / chemistry
Substances
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1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)
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Antibiotics, Antineoplastic
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Cations
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Drug Carriers
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Macrocyclic Compounds
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Surface-Active Agents
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Doxorubicin
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Calcitriol