Abstract
A new antimicrobial and cytotoxic sesquiterpenoid, lentinellic acid, has been isolated from submerged cultures of Lentinellus ursinus and L. omphalodes. The structure of the antibiotic was elucidated by spectroscopic methods and a single crystal X-ray analysis. 1 may be formed biogenetically by condensation of a protoilludane aldehyde 4 with a malonate unit.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / isolation & purification*
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Bacteria / drug effects
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Basidiomycota / growth & development*
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Fermentation
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Fungi / drug effects
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
Substances
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Antibiotics, Antineoplastic
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Sesquiterpenes
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lentinellic acid