PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease
Am J Hematol
.
2021 Aug 1;96(8):E272-E275.
doi: 10.1002/ajh.26204.
Epub 2021 May 13.
Authors
Kelly M Knee
1
,
Reema Jasuja
1
,
Amey Barakat
1
,
Dharani Rao
1
,
Zane Wenzel
2
,
Jayasankar Jasti
3
,
Jonathan Novak
4
,
Kevin Beaumont
4
,
David W Piotrowski
5
,
Phil Jeffrey
1
,
Christine Bulawa
1
,
John E Murphy
1
,
Jay M Janz
1
Affiliations
1
Rare Disease Research Unit, Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts, USA.
2
Primary Pharmacology Group, Pfizer Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, Connecticut, USA.
3
Discovery Sciences, Pfizer Worldwide Research, Development and Medical, Groton, Connecticut, USA.
4
Pharmacokinetics, Dynamics, Metabolism, Pfizer Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, Connecticut, USA.
5
Pfizer Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, Connecticut, USA.
PMID:
33891711
PMCID:
PMC8360071
DOI:
10.1002/ajh.26204
No abstract available
Publication types
Letter
MeSH terms
Anemia, Sickle Cell / blood*
Animals
Disease Models, Animal
Hemoglobins / metabolism*
Mice
Substances
Hemoglobins