Risk Factors for the Incidence and Severity of Acute Kidney Injury After Liver Transplantation

Dali Zhang; Zhenwen Liu; Jing Feng Bi; Hongling Liu; Yinjie Gao

doi:10.5152/tjg.2020.19592

Risk Factors for the Incidence and Severity of Acute Kidney Injury After Liver Transplantation

Turk J Gastroenterol. 2021 Jan;32(1):82-87. doi: 10.5152/tjg.2020.19592.

Authors

Dali Zhang¹, Zhenwen Liu¹, Jing Feng Bi², Hongling Liu¹, Yinjie Gao¹

Affiliations

¹ Liver Transplantation and Research Center, 302 Hospital, Beijing, China.
² Research and Technology Service Center, 302 Hospital, Beijing, China.

Abstract

Background/aims: To explore risk factors of acute kidney injury (AKI) and its severity after liver transplantation.

Materials and methods: This was a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital. Risk factors for AKI from 1week post-liver transplantation and 4-week outcomes were analysed. Further analyses of factors that influenced the severity of AKI were also performed.

Results: A total of 204 patients were included. AKI was found in 55.4% of patients in the first week after OLT. Risk factors for AKI were recipient's sex, BMI, preoperative creatinine, preoperative hepatic encephalopathy, cold ischaemia time, duration of surgery, duration of inferior vena clamping, postoperative peak lactate and postoperative peak AST, which were higher in the AKI group. Four weeks after liver transplantation, 20.4% of AKI patients still had abnormal renal function and a mortality rate of 3.6%, and these values were significantly higher than those of patients without AKI (P<0.05).

Conclusion: Preoperative, intraoperative and postoperative factors can all lead to AKI after OLT.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury* / etiology
Adult
End Stage Liver Disease* / surgery
Female
Humans
Incidence
Liver Transplantation* / adverse effects
Male
Middle Aged
Patient Acuity
Retrospective Studies
Risk Factors

Grants and funding

This work was supported by Tianqing liver disease research fund (Grant No. TQGB20170133) with Department of Liver Transplantation Center. The department disclaims responsibility for the analysis and conclusions.