Prenatal exposure to residential PM_2.5 and its chemical constituents and weight in preschool children: A longitudinal study from Shanghai, China

Background: Studies have reported that prenatal exposure to fine particulate matter (PM_2.5) might be associated with adverse birth outcomes in offspring. However, evidence with regard to the effects of prenatal exposure to PM_2.5 and, especially, its main chemical constituents on offspring's weight in childhood is limited and inconsistent.

Objectives: The present study aimed to examine associations of prenatal exposure to PM_2.5 total mass and its chemical constituents in each trimester with children's weight from birth to 6 years of age using data from Shanghai-Minhang Birth Cohort Study.

Methods: A total of 1,084 mother-infant pairs were included with both PM_2.5 exposure data and at least one measurement of weight and height. Weight-for-Length (WLZ), BMI-for-Age (BMIz), and Weight-for-Age (WAZ) z-scores were generated according to the World Health Organization guidelines. Exposure to PM_2.5 total mass and its chemical constituents [organic carbon (OC), black carbon (BC), ammonium (NH₄⁺), nitrate (NO₃^-), sulfate (SO₄^2-), and soil dust (SOIL)] during pregnancy was estimated from a satellite based modelling framework. We used multiple informant model to estimate the associations of trimester-specific PM_2.5 total mass and its specific constituents concentrations with WLZ/BMIz and WAZ of offspring at birth and 1, 4, and 6 years of age.

Results: In multiple informant model, we observed consistent patterns of associations between exposure to PM_2.5 total mass, OC, BC, NH₄⁺, NO₃^-, and SO₄^2- during the 2^nd and 3^rd trimesters and decreased WLZ/BMIz and WAZ at 1, 4, and 6 years of age in boys. We observed associations between prenatal exposure to PM_2.5 total mass, NH₄⁺, and NO₃^- during the 1^st and 2^nd trimesters and increased WLZ/BMIz and WAZ in girls at birth. However, there were null associations at 1 and 4 years of age and inverse associations at 6 years of age.

Conclusions: Prenatal exposure to PM_2.5 total mass and its main chemical constituents was associated with decreased weight in boys from 1 to 6 years of age, with increased weight at birth and decreased weight at 6 years of age in girls. Our findings suggest that prenatal exposure to PM_2.5 and its chemical constituents may have a lasting effect on offspring's weight in childhood.