Performance of Repeat BinaxNOW Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Testing in a Community Setting, Wisconsin, November 2020-December 2020

Melisa M Shah; Phillip P Salvatore; Laura Ford; Emiko Kamitani; Melissa J Whaley; Kaitlin Mitchell; Dustin W Currie; Clint N Morgan; Hannah E Segaloff; Shirley Lecher; Tarah Somers; Miriam E Van Dyke; John Paul Bigouette; Augustina Delaney; Juliana DaSilva; Michelle O'Hegarty; Lauren Boyle-Estheimer; Fatima Abdirizak; Sandor E Karpathy; Jennifer Meece; Lynn Ivanic; Kimberly Goffard; Doug Gieryn; Alana Sterkel; Allen Bateman; Juliana Kahrs; Kimberly Langolf; Tara Zochert; Nancy W Knight; Christopher H Hsu; Hannah L Kirking; Jacqueline E Tate

doi:10.1093/cid/ciab309

Performance of Repeat BinaxNOW Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Testing in a Community Setting, Wisconsin, November 2020-December 2020

Clin Infect Dis. 2021 Jul 15;73(Suppl 1):S54-S57. doi: 10.1093/cid/ciab309.

Authors

Melisa M Shah^{1

2}, Phillip P Salvatore^{1

2}, Laura Ford^{1

2}, Emiko Kamitani¹, Melissa J Whaley¹, Kaitlin Mitchell^{1

3}, Dustin W Currie^{1

2}, Clint N Morgan¹, Hannah E Segaloff^{1

2

4}, Shirley Lecher¹, Tarah Somers¹, Miriam E Van Dyke^{1

2}, John Paul Bigouette^{1

2}, Augustina Delaney¹, Juliana DaSilva¹, Michelle O'Hegarty¹, Lauren Boyle-Estheimer¹, Fatima Abdirizak¹, Sandor E Karpathy¹, Jennifer Meece⁵, Lynn Ivanic⁵, Kimberly Goffard⁶, Doug Gieryn⁶, Alana Sterkel⁷, Allen Bateman⁷, Juliana Kahrs⁸, Kimberly Langolf⁸, Tara Zochert⁸, Nancy W Knight¹, Christopher H Hsu¹, Hannah L Kirking¹, Jacqueline E Tate¹

Affiliations

¹ COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
³ Laboratory Leadership Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
⁴ Wisconsin Department of Health Services, Madison, Wisconsin, USA.
⁵ Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
⁶ Winnebago County Health Department, Oshkosh, Wisconsin, USA.
⁷ Wisconsin State Laboratory of Hygiene, Madison, Wisconsin, USA.
⁸ University of Wisconsin-Oshkosh, Oshkosh, Wisconsin, USA.

Abstract

Repeating the BinaxNOW antigen test for severe acute respiratory syndrome coronavirus 2 using 2 groups of readers within 30 minutes resulted in high concordance (98.9%) in 2110 encounters. Same-day repeat antigen testing did not significantly improve test sensitivity (77.2% to 81.4%) while specificity remained high (99.6%).

Keywords: BinaxNOW; COVID-19; SARS-CoV-2; antigen testing; diagnostic performance.

Published by Oxford University Press for the Infectious Diseases Society of America 2021.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

COVID-19 Testing
COVID-19*
Humans
SARS-CoV-2*
Sensitivity and Specificity
Wisconsin / epidemiology

Grants and funding

CC/CDC HHS/United States