METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e325-e337. doi: 10.1161/ATVBAHA.121.316180. Epub 2021 Apr 29.

Affiliations

¹ National Heart and Lung Institute, Imperial College London, United Kingdom (A.C.-J., W.K.S., M.A., I.R.-P., C.E.).
² School of Biomedical Sciences, Department of Physiology HeartOtago, University of Otago, Dunedin, New Zealand (R.K., D.C.).
³ Bristol Heart Institute, University of Bristol, United Kingdom (M.B., G.S.-N.).
⁴ Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, University of Sydney, NSW, Australia (M.B.).
⁵ Biodiscovery Institute, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, United Kingdom (N.B.-L., A.A.R., A.V.B.).

PMID: 33910374
DOI: 10.1161/ATVBAHA.121.316180

Abstract

[Figure: see text].

Keywords: endothelial cell; gene expression; homeostasis; microRNA; thrombospondin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine / analogs & derivatives
Adenosine / metabolism
Animals
Cells, Cultured
Disease Models, Animal
Female
Gene Expression Regulation
Hindlimb / blood supply*
Human Umbilical Vein Endothelial Cells / enzymology*
Humans
Ischemia / enzymology*
Ischemia / genetics
Ischemia / physiopathology
Male
Methyltransferases / genetics
Methyltransferases / metabolism*
Mice
Mice, Inbred C57BL
MicroRNAs / genetics
MicroRNAs / metabolism*
Myocardial Infarction / enzymology*
Myocardial Infarction / genetics
Myocardial Infarction / physiopathology
Neovascularization, Physiologic*
Signal Transduction
Thrombospondin 1 / genetics
Thrombospondin 1 / metabolism

Substances

MIRN18 microRNA, human
MicroRNAs
Thrombospondin 1
mirnlet7 microRNA, human
thrombospondin-1, human
N-methyladenosine
Methyltransferases
Mettl3 protein, mouse
METTL3 protein, human
Adenosine

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