Chronic myeloid leukemia with a significant increase of monocytes is rare and difficult to identify from chronic myelo-monocytic leukemia in clinic. A 31-year-old male patient with systemic pain was initially diagnosed as chronic myelo-monocytic leukemia, who was finally diagnosed as chronic myeloid leukemia by fusion gene and chromosome examination. In addition to the typical Ph chromosome, a rare chromosome translocation t(2; 7)(p13; p22) was observed. The detection of monocyte subsets by multi-parameter flow cytometry is a diagnostic marker to distinguish the above 2 diseases. The relationship between fusion genes and mononucleosis is not clear. Tyrosine kinase inhibitors or allogeneic hematopoietic stem cell transplantation can be used in the treatment for this disease.
单核细胞增加的慢性粒细胞白血病临床少见，与慢性粒-单核细胞白血病难以鉴别。1例31岁男性患者，以全身疼痛起病，初步诊断为慢性粒单核细胞白血病，经融合基因和染色体等检查最终确诊为慢性粒细胞白血病。除了典型的Ph染色体外，还发现罕见的染色体易位t(2; 7)(p13; p22)。流式细胞学检测单核细胞亚群有助于鉴别诊断，融合基因与单核细胞增加的关系尚不明确。采用酪氨酸激酶抑制剂或者异基因造血干细胞移植治疗。.
Keywords: 7) (p13; chromosome translocation t(2; chronic myeloid leukemia; chronic myelomonocytic leukemia; p22).