Skeletal Muscle Nrf2 Contributes to Exercise-Evoked Systemic Antioxidant Defense Via Extracellular Vesicular Communication

Exerc Sport Sci Rev. 2021 Jul 1;49(3):213-222. doi: 10.1249/JES.0000000000000257.

Abstract

This review explores the hypothesis that the repetitive contraction-relaxation that occurs during chronic exercise activates skeletal myocyte nuclear factor erythroid-derived 2-like 2 (Nrf2) to upregulate antioxidant enzymes. These proteins are secreted into the circulation within extracellular vesicles and taken up by remote cells, thus providing remote organs with cytoprotection against subsequent oxidative stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antioxidants* / metabolism
  • Communication
  • Muscle, Skeletal / metabolism
  • NF-E2-Related Factor 2* / metabolism
  • Oxidative Stress

Substances

  • Antioxidants
  • NF-E2-Related Factor 2