International Trends in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Incidence

Am J Gastroenterol. 2021 May 1;116(5):1072-1076. doi: 10.14309/ajg.0000000000001121.

Abstract

Introduction: We aimed to improve our understanding of the epidemiology of squamous cell carcinoma and adenocarcinoma of the esophagus.

Methods: We estimated average annual percent change and analyzed age-period-cohort trends on population-based cancer data.

Results: We found decreases in squamous cell carcinoma incidence in half of male populations (largest decrease in US black males [average annual percent change -7.6]) and increases in adenocarcinoma incidence in nearly a third of populations. Trends may be associated with a mix of birth cohort and period effects.

Discussion: More complete data and evidence are needed to conclude the reasons for the observed trends (see Visual Abstract, Supplementary Digital Content 4, http://links.lww.com/AJG/B823).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology*
  • Adult
  • Aged
  • Esophageal Squamous Cell Carcinoma / epidemiology*
  • Female
  • Global Health*
  • Humans
  • Incidence
  • Male
  • Middle Aged