Concurrent zinc and vitamin B₆ deficiencies in acutely exacerbated inflammatory bowel disease: Case reports

Background: Limited evidence is available to describe the prevalence, causes, and consequences of zinc and vitamin B₆ deficiencies in those with acutely exacerbated inflammatory bowel disease (IBD). Zinc is important for immune function and wound healing, and B₆ is needed for metabolic and neurological function. Patients with IBD are at risk of micronutrient deficiencies, particularly during flares.

Presentations: The cases of 2 patients with IBD exacerbations were reviewed in which deficiencies of both zinc and vitamin B₆ were identified.

Conclusions: These cases highlight the need for increased screening for zinc and pyridoxine deficiencies in IBD population, especially during disease exacerbation. Therefore, we recommend a comprehensive nutrition workup with physical exam, diet history, and a complete micronutrient panel while ruling out contributing factors. If patients are susceptible to deficiencies during flares, prophylactic oral zinc and pyridoxine supplementation may be considered, with close monitoring for subsequent iron and copper deficiencies.