Abstract
Primary IgA plasma cell leukemia is a rare disorder in which hyperviscosity has not been reported. We studied a patient with plasma cell leukemia and IgA lambda monoclonal gammopathy with an elevated relative serum viscosity and congestive heart failure. Plasmapheresis and chemotherapy were successful in controlling symptoms. We discuss this unusual association and review the literature.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols*
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Blood Viscosity*
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Cyclophosphamide / therapeutic use
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Cytarabine / therapeutic use
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Doxorubicin / therapeutic use
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Etoposide / therapeutic use
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Heart Failure / complications
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Heart Failure / therapy
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Humans
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Immunoglobulin A*
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Leukemia, Plasma Cell / blood
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Leukemia, Plasma Cell / complications*
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Leukemia, Plasma Cell / drug therapy
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Male
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Middle Aged
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Paraproteinemias / complications*
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Plasmapheresis
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Prednisone / therapeutic use
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Vincristine / therapeutic use
Substances
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Immunoglobulin A
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Cytarabine
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Vincristine
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Etoposide
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Doxorubicin
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Cyclophosphamide
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Prednisone