Measuring the size and decay dynamics of the HIV-1 latent reservoir

Runxia Liu; Allison A Catalano; Ya-Chi Ho

doi:10.1016/j.xcrm.2021.100249

Measuring the size and decay dynamics of the HIV-1 latent reservoir

Cell Rep Med. 2021 Apr 20;2(4):100249. doi: 10.1016/j.xcrm.2021.100249.

Authors

Runxia Liu¹, Allison A Catalano^{1

2}, Ya-Chi Ho¹

Affiliations

¹ Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
² Department of Epidemiology of Microbial Diseases, Yale University School of Public Health, New Haven, CT 06519, USA.

Abstract

Measuring HIV-1 latent reservoir is essential for HIV-1 cure strategies. Levy et al.¹ developed a multiplex droplet digital PCR (ddPCR) assay-5-target intact proviral DNA assay-to detect multiple regions of HIV-1 proviral genome and increase accuracy.

Publication types

Comment

MeSH terms

DNA, Viral / genetics
HIV Infections*
HIV Seropositivity*
HIV-1* / genetics
Humans
Proviruses / genetics

Substances

DNA, Viral

Grants and funding

UL1 TR001863/TR/NCATS NIH HHS/United States