High dose methotrexate therapy: insecure rationale?

Biochem Pharmacol. 1988 Jul 15;37(14):2713-5. doi: 10.1016/0006-2952(88)90032-9.

Authors

B A Kamen¹, N J Winick

Affiliation

¹ Department of Pediatrics, University of Texas Health Science Center, Southwestern Medical School, Dallas 75235.

PMID: 3395351
DOI: 10.1016/0006-2952(88)90032-9

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance
Folic Acid Antagonists
Humans
Methotrexate / administration & dosage*
Methotrexate / metabolism
Neoplasms / drug therapy*
Thymidylate Synthase / analysis

Substances

Folic Acid Antagonists
Thymidylate Synthase
Methotrexate