Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Hypertension. 2021 Aug;78(2):499-511. doi: 10.1161/HYPERTENSIONAHA.120.16895. Epub 2021 May 10.

Authors

Affiliations

¹ From the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
² Department of Food Science and Technology (A.P.N.).
³ Now with Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis (A.P.N.).
⁴ Department of Human Nutrition, Foods, and Exercise (K.P.D.), Virginia Tech, Blacksburg.

Abstract

[Figure: see text].

Keywords: advanced glycation end products; arterial stiffness; gut microbiota; pulse wave velocity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adolescent
Adult
Age Factors
Aged
Aging / blood*
Animals
Aorta / drug effects*
Aorta / physiology
Blood Pressure / drug effects*
Blood Pressure / physiology
Female
Humans
Male
Methylamines / administration & dosage
Methylamines / blood*
Mice
Middle Aged
Pulse Wave Analysis
Vascular Stiffness / drug effects*
Vascular Stiffness / physiology
Young Adult

Substances

Methylamines
trimethyloxamine

Grants and funding