Identification of hepatitis delta superinfection when investigating transaminitis in HIV/hepatitis B virus co-infection

Ali Hamady; Graham S Cooke; Lucy J Garvey

doi:10.1097/QAD.0000000000002940

Identification of hepatitis delta superinfection when investigating transaminitis in HIV/hepatitis B virus co-infection

AIDS. 2021 Aug 1;35(10):1704-1706. doi: 10.1097/QAD.0000000000002940.

Authors

Ali Hamady¹, Graham S Cooke^{1

2}, Lucy J Garvey²

Affiliations

¹ Division of Medicine, Imperial College.
² Division of Medicine, Imperial College Healthcare NHS Trust, London, UK.

PMID: 33973877
DOI: 10.1097/QAD.0000000000002940

Abstract

Hepatitis delta virus (HDV) is a highly pathogenic virus which can cause rapidly progressive liver disease in individuals with chronic hepatitis B virus and for which treatment options are limited. The incidence of sexually transmitted HDV infection is unknown. Here we report the case of a HDV seronegative man with pre-existent HIV/hepatitis B virus, taking effective tenofovir-containing antiretroviral therapy, who experienced a significant acute transaminitis with HDV antibody seroconversion and viraemia and no other identifiable cause.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Coinfection*
HIV Infections* / complications
HIV Infections* / drug therapy
Hepatitis B virus
Hepatitis B* / complications
Hepatitis B, Chronic* / complications
Hepatitis D* / complications
Hepatitis D* / diagnosis
Hepatitis Delta Virus
Humans
Male
Superinfection*