Intratumoral bacteria generate a new class of therapeutically relevant tumor antigens in melanoma

Gregory D Sepich-Poore; Hannah Carter; Rob Knight

doi:10.1016/j.ccell.2021.04.008

Intratumoral bacteria generate a new class of therapeutically relevant tumor antigens in melanoma

Cancer Cell. 2021 May 10;39(5):601-603. doi: 10.1016/j.ccell.2021.04.008.

Authors

Gregory D Sepich-Poore¹, Hannah Carter², Rob Knight³

Affiliations

¹ Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
² Department of Medicine, University of California San Diego, La Jolla, CA, USA.
³ Department of Bioengineering, University of California San Diego, La Jolla, CA, USA; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA; Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA. Electronic address: [email protected].

PMID: 33974857
DOI: 10.1016/j.ccell.2021.04.008

Abstract

The functional repertoire of intratumoral microorganisms and their local effects on the host remain poorly characterized. By revealing potentially immunogenic bacterial peptides on melanoma cells, a Nature paper provides evidence that intratumoral bacteria can directly modulate antitumor immune responses, and it details a new class of therapeutically relevant, non-human tumor antigens.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antigens, Neoplasm* / genetics
Bacteria
Humans
Immunity
Melanoma* / drug therapy
Melanoma* / genetics
Peptides

Substances

Antigens, Neoplasm
Peptides

Grants and funding

F30 CA243480/CA/NCI NIH HHS/United States