Fungus fuels mucosal wounds in Crohn's disease

Kevin M Magnaye; Susan V Lynch

doi:10.1016/j.immuni.2021.04.013

Fungus fuels mucosal wounds in Crohn's disease

Immunity. 2021 May 11;54(5):856-858. doi: 10.1016/j.immuni.2021.04.013.

Authors

Kevin M Magnaye¹, Susan V Lynch²

Affiliations

¹ Department of Medicine, University of California, San Francisco, CA, USA.
² Department of Medicine, University of California, San Francisco, CA, USA. Electronic address: [email protected].

PMID: 33979584
DOI: 10.1016/j.immuni.2021.04.013

Abstract

Intestinal microbiome perturbation characterizes Crohn's disease (CD), though specific contributors to pathophysiology remain elusive. In a recent issue of Science, Jain et al. show that Debaryomyces hansenii impairs intestinal healing in mice via effects on type I interferon signaling and chemokine CCL5 expression in macrophages and that it is also prevalent in the inflamed mucosa of CD patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chemokine CCL5 / immunology
Crohn Disease / immunology*
Crohn Disease / microbiology*
Gastrointestinal Microbiome / immunology
Humans
Interferon Type I / immunology
Intestinal Mucosa / immunology
Intestinal Mucosa / microbiology*
Macrophages / immunology
Mice
Mycoses / immunology
Mycoses / microbiology
Saccharomycetales / immunology
Signal Transduction / immunology
Wound Healing / immunology*

Substances

Chemokine CCL5
Interferon Type I

Supplementary concepts

Debaryomyces fabryi