Blocking FcγRIIB in Smooth Muscle Cells Reduces Hypertension

Circ Res. 2021 Jul 9;129(2):308-325. doi: 10.1161/CIRCRESAHA.120.318447. Epub 2021 May 13.

Xiaomin Song^#¹, Xuan Zou^#¹, Weipeng Ge¹, Cuiliu Hou¹, Zhujie Cao¹, Hongmei Zhao¹, Tiantian Zhang², Ling Jin³, Yi Fu^{4

5}, Wei Kong^{4

5}, Chen Yan⁶, Jun Cai³, Jing Wang¹

¹ Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (X.S., X.Z., W.G., C.H., Z.C., H.Z., J.W.), Chinese Academy of Medical Sciences, Peking Union Medical College, China.
² Department Physiology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (T.Z.), Chinese Academy of Medical Sciences, Peking Union Medical College, China.
³ State Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Center of Laboratory Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases (L.J., J.C.), Chinese Academy of Medical Sciences, Peking Union Medical College, China.
⁴ Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China (Y.F., W.K.).
⁵ Key Laboratory of Molecular Cardiovascular Science, Ministry of Education (Y.F., W.K.).
⁶ Aab Cardiovascular Research Institute, Medicine, University of Rochester School of Medicine and Dentistry, NY (C.Y.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: arteries; hypertension; hypertrophy; myocytes, smooth muscle; receptors, angiotensin.