Correction of Familial LCAT Deficiency by AAV-hLCAT Prevents Renal Injury and Atherosclerosis in Hamsters-Brief Report

Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2141-2148. doi: 10.1161/ATVBAHA.120.315719. Epub 2021 May 13.

Authors

Mengmeng Guo^{1

2}, Sisi Ma², Yitong Xu³, Wei Huang¹, Mingming Gao³, Xiaobing Wu², Xiaoyan Dong⁴, Yuhui Wang¹, George Liu¹, Xunde Xian¹

Affiliations

¹ Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, School of Basic Medical Sciences, Peking University, Beijing, China (M.G., W.H., Y.W., G.L., X.X.).
² Beijing GeneCradle Pharmaceutical Co, Ltd, Beijing, China (M.G., S.M., X.W.).
³ Laboratory of Lipid Metabolism, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, China (Y.X., M.G.).
⁴ Beijing FivePlus Molecular Medicine Institute Co, Ltd, Beijing, China (X.D.).

PMID: 33980035
DOI: 10.1161/ATVBAHA.120.315719

Abstract

[Figure: see text].

Keywords: LCAT; atherosclerosis; cardiovascular diseases; dyslipidemias; gene therapy; hamster.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Genetically Modified
Apolipoprotein A-I / blood
Atherosclerosis / enzymology
Atherosclerosis / genetics
Atherosclerosis / prevention & control*
Cholesterol, HDL / blood
Dependovirus / genetics*
Disease Models, Animal
Genetic Therapy*
Genetic Vectors
Kidney Diseases / enzymology
Kidney Diseases / genetics
Kidney Diseases / prevention & control*
Lecithin Cholesterol Acyltransferase Deficiency / enzymology
Lecithin Cholesterol Acyltransferase Deficiency / genetics
Lecithin Cholesterol Acyltransferase Deficiency / therapy
Lipids / blood*
Male
Mesocricetus / genetics
Phosphatidylcholine-Sterol O-Acyltransferase / genetics
Phosphatidylcholine-Sterol O-Acyltransferase / metabolism*
Triglycerides / blood

Substances

Apolipoprotein A-I
Cholesterol, HDL
Lipids
Triglycerides
LCAT protein, human
Phosphatidylcholine-Sterol O-Acyltransferase