Effectiveness and mechanisms of enriched environment in post-stroke cognitive impairment

Mei Yuan; Yi-Sha Guo; Yu Han; Zhen-Kun Gao; Xin-Ya Shen; Xia Bi

doi:10.1016/j.bbr.2021.113357

Effectiveness and mechanisms of enriched environment in post-stroke cognitive impairment

Behav Brain Res. 2021 Jul 23:410:113357. doi: 10.1016/j.bbr.2021.113357. Epub 2021 May 11.

Authors

Mei Yuan¹, Yi-Sha Guo², Yu Han³, Zhen-Kun Gao⁴, Xin-Ya Shen⁵, Xia Bi⁶

Affiliations

¹ Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China. Electronic address: [email protected].
² Shanghai University of Sport, Shanghai, 200438, China. Electronic address: [email protected].
³ Shanghai University of Sport, Shanghai, 200438, China. Electronic address: [email protected].
⁴ Shanghai University of Traditionary Chinese Medicine, Shanghai, 201203, China. Electronic address: [email protected].
⁵ Shanghai University of Traditionary Chinese Medicine, Shanghai, 201203, China. Electronic address: [email protected].
⁶ Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China. Electronic address: [email protected].

PMID: 33989729
DOI: 10.1016/j.bbr.2021.113357

Abstract

Post-stroke cognitive impairment (PSCI) is one of the most common complications of stroke, it is also an important reason for the poor prognosis in stroke patients with motor and speech dysfunction. Enriched Environment (EE), a novel and easy-to-implement rehabilitation treatment strategy, is thought to be a potential intervention for PSCI recently. In this paper, we review the therapeutic effects and related mechanisms of EE in PSCI from the level of animal research and clinical application. Besides, we further discuss the application prospects and limitations of EE in PSCI patients.

Keywords: Enriched environment; Mechanism; Post-stroke cognitive impairment; Treatment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cognitive Dysfunction / etiology
Cognitive Dysfunction / rehabilitation*
Environment*
Humans
Outcome Assessment, Health Care*
Recreation Therapy*
Stroke / complications
Stroke / therapy*
Stroke Rehabilitation*