Acute myocardial infarction in a 41-year-old woman due to elevated factor VIII: a case report

Pan Afr Med J. 2021 Feb 24:38:207. doi: 10.11604/pamj.2021.38.207.28011. eCollection 2021.

Abstract

Myocardial infarction is a life-threatening emergency with a high mortality rate. A high plasma level of factor VIII is an established risk for both arterial and venous thrombotic events. In this mini-review, we report the case of a 41-year-old woman without cardiovascular risk factors or a previous history of thrombotic events, admitted for ST-elevation myocardial infarction, in whom coronary angiography showed a thrombotic occlusion in the left anterior descending artery. The patient underwent primary percutaneous coronary intervention (PCI), with GPIIB-IIIA antagonist, then, a pre-dilation with a semi-compliant balloon-catheter, followed by implantation of 2 stents. The etiological assessment revealed a high level of coagulation factor VIII (FVIII). She underwent anticoagulation therapy (with acenocoumarol) with well-controlled international normalised ratio (INR).

Keywords: Acute myocardial infarction; case report; coagulation factor VIII; coronary artery thrombosis; thrombophilia.

Publication types

  • Case Reports

MeSH terms

  • Acenocoumarol / administration & dosage
  • Adult
  • Anticoagulants / administration & dosage
  • Coronary Angiography*
  • Factor VIII / metabolism*
  • Female
  • Humans
  • Percutaneous Coronary Intervention / methods*
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors
  • ST Elevation Myocardial Infarction / blood
  • ST Elevation Myocardial Infarction / diagnosis*
  • ST Elevation Myocardial Infarction / therapy
  • Stents
  • Thrombosis / diagnostic imaging

Substances

  • Anticoagulants
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • F8 protein, human
  • Factor VIII
  • Acenocoumarol