Left ventricular responses to handgrip exercise test in patients with ischemic heart disease were assessed by RI methods. We subdivided into three groups (A: delta EF more than 5% increased, B: delta EF -5%-+5% no change, C: delta EF less than 5% reduced), left ventricular contractility (LVEF/LVET) and Tl defect score changed significantly in global EF reduced group, moreover the usefulness of handgrip test was assured. This instrument is low cost, safety, small size, and available for wide ranged ages.