Total body irradiation-based haploidentical hematopoietic stem cell transplantation using posttransplant cyclophosphamide after administration of inotuzumab ozogamicin: A case report

Masaya Abe; Nobuharu Fujii; Kentaro Mizuhara; Tomohiro Urata; Yuichi Sumii; Yuki Fujiwara; Keisuke Seike; Yasuhisa Sando; Makoto Nakamura; Keiko Fujii; Kyosuke Saeki; Yusuke Meguri; Noboru Asada; Daisuke Ennishi; Hisakazu Nishimori; Ken-Ichi Matsuoka; Yoshinobu Maeda

doi:10.1016/j.lrr.2021.100241

Total body irradiation-based haploidentical hematopoietic stem cell transplantation using posttransplant cyclophosphamide after administration of inotuzumab ozogamicin: A case report

Leuk Res Rep. 2021 Apr 22:15:100241. doi: 10.1016/j.lrr.2021.100241. eCollection 2021.

Authors

Masaya Abe¹, Nobuharu Fujii^{1

2}, Kentaro Mizuhara¹, Tomohiro Urata¹, Yuichi Sumii¹, Yuki Fujiwara¹, Keisuke Seike², Yasuhisa Sando², Makoto Nakamura², Keiko Fujii², Kyosuke Saeki¹, Yusuke Meguri¹, Noboru Asada¹, Daisuke Ennishi¹, Hisakazu Nishimori¹, Ken-Ichi Matsuoka¹, Yoshinobu Maeda¹

Affiliations

¹ Department of Hematology and Oncology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama Prefecture 700-8558, Japan.
² Department of Transfusion Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama Prefecture 700-8558, Japan.

Abstract

Owing to the poor prognosis of relapsed or refractory acute lymphoblastic leukemia (ALL), hematopoietic stem cell transplantation (HSCT) followed by effective salvage therapy is required. Inotuzumab ozogamicin (INO) was developed for ALL refractory to standard chemotherapy. However, previous reports suggest that sinusoidal obstruction syndrome (SOS) risk increases in patients with HSCT receiving INO, especially with dual alkylating agents. We report a case of relapsed Philadelphia chromosome-negative B-ALL where the patient underwent haploidentical HSCT using fludarabine/total body irradiation conditioning and posttransplant cyclophosphamide. Successful engraftment was achieved without SOS development.

Keywords: Acute lymphoblastic leukemia; Hematopoietic stem cell transplantation; Inotuzumab ozogamicin; Posttransplant cyclophosphamide; Sinusoidal obstruction syndrome.

Publication types

Case Reports