Identification of Anemia for Predicting Mid-Term Prognosis After Transcatheter Aortic Valve Implantation in Japanese Patients - Insights From the OCEAN-TAVI Registry

Hiroshi Onoda; Hiroshi Ueno; Teruhiko Imamura; Yohei Ueno; Hiroyuki Kuwahara; Mitsuo Sobajima; Koichiro Kinugawa; Norio Tada; Toru Naganuma; Masahiro Yamawaki; Futoshi Yamanaka; Shinichi Shirai; Kazuki Mizutani; Minoru Tabata; Kensuke Takagi; Yusuke Watanabe; Masanori Yamamoto; Kentaro Hayashida; OCEAN-TAVI Investigators

doi:10.1253/circrep.CR-21-0026

Identification of Anemia for Predicting Mid-Term Prognosis After Transcatheter Aortic Valve Implantation in Japanese Patients - Insights From the OCEAN-TAVI Registry

Circ Rep. 2021 Apr 7;3(5):286-293. doi: 10.1253/circrep.CR-21-0026.

Authors

Hiroshi Onoda¹, Hiroshi Ueno¹, Teruhiko Imamura¹, Yohei Ueno¹, Hiroyuki Kuwahara¹, Mitsuo Sobajima¹, Koichiro Kinugawa¹, Norio Tada², Toru Naganuma^{3

4}, Masahiro Yamawaki⁵, Futoshi Yamanaka^{4

6}, Shinichi Shirai⁷, Kazuki Mizutani⁸, Minoru Tabata⁹, Kensuke Takagi¹⁰, Yusuke Watanabe¹¹, Masanori Yamamoto^{12

13}, Kentaro Hayashida¹⁴; OCEAN-TAVI Investigators

Affiliations

¹ Second Department of Internal Medicine, University of Toyama Toyama Japan.
² Department of Cardiology, Sendai Kousei Hospital Sendai Japan.
³ Department of Cardiology, New Tokyo Hospital Matsudo Japan.
⁴ Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan.
⁵ Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital Yokohama Japan.
⁶ Department of Cardiology, Shonan Kamakura General Hospital Kamakura Japan.
⁷ Department of Cardiology, Kokura Memorial Hospital Kitakyushu Japan.
⁸ Division of Cardiology, Department of Medicine, Faculty of Medicine, Kindai University Osakasayama Japan.
⁹ Department of Cardiovascular Surgery, Tokyo Bay Urayasu Ichikawa Medical Center Urayasu Japan.
¹⁰ Department of Cardiology, Ogaki Municipal Hospital Ogaki Japan.
¹¹ Department of Cardiology, Teikyo University School of Medicine Tokyo Japan.
¹² Department of Cardiology, Toyohashi Heart Center Toyohashi Japan.
¹³ Department of Cardiology, Nagoya Heart Center Nagoya Japan.
¹⁴ Department of Cardiology, Keio University School of Medicine Tokyo Japan.

Abstract

Background: Patients with anemia have a poor prognosis following transcatheter aortic valve implantation (TAVI). Given the unique distribution of hemoglobin levels in the Japanese cohort, the optimal cut-off hemoglobin value may help stratify Japanese patients' mortality following TAVI. Methods and Results: Data of patients who underwent TAVI were collected from the prospective multicenter Optimized transCathEter vAlvular iNtervention (OCEAN)-TAVI Registry. Receiver operating characteristic analysis was used to calculate a hemoglobin cut-off value to stratify 2-year mortality following TAVI. In all, 2,588 patients (mean [±SD] age 84.4±5.2 years, 795 men) were included in the study. Of these patients, 909 (35.1%) had anemia, which was defined as hemoglobin <10.9 g/dL for men and <10.4 g/dL for women. The presence of anemia, uniquely defined for the Japanese cohort, was independently associated with 2-year mortality following TAVI, with an odds ratio of 1.77 (95% confidence interval 1.39-2.25) adjusted for 14 other clinical variables. Conclusions: The existence of anemia, uniquely defined for the Japanese cohort, was associated with mid-term mortality following TAVI.

Keywords: Aortic stenosis; Prognosis; Transcatheter aortic valve implantation.