SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity

Lancet Infect Dis. 2021 Aug;21(8):1070. doi: 10.1016/S1473-3099(21)00262-0. Epub 2021 May 19.

Authors

Muthukumar Ramanathan¹, Ian D Ferguson², Weili Miao², Paul A Khavari³

Affiliations

¹ Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
³ Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: [email protected].

No abstract available

Publication types

Letter

MeSH terms

Angiotensin-Converting Enzyme 2 / metabolism*
COVID-19 / transmission*
Humans
SARS-CoV-2 / pathogenicity*
Spike Glycoprotein, Coronavirus / metabolism*

Substances

Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
ACE2 protein, human
Angiotensin-Converting Enzyme 2