The clinical role of host and bacterial-derived extracellular vesicles in pneumonia

Anna Lena Jung; Bernd Schmeck; Marie Wiegand; Katrin Bedenbender; Birke J Benedikter

doi:10.1016/j.addr.2021.05.021

The clinical role of host and bacterial-derived extracellular vesicles in pneumonia

Adv Drug Deliv Rev. 2021 Sep:176:113811. doi: 10.1016/j.addr.2021.05.021. Epub 2021 May 20.

Authors

Anna Lena Jung¹, Bernd Schmeck², Marie Wiegand³, Katrin Bedenbender⁴, Birke J Benedikter⁵

Affiliations

¹ Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany. Electronic address: [email protected].
² Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany; Department of Pulmonary and Critical Care Medicine, University Medical Center Marburg, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Hesse, Germany; Member of the German Center for Lung Research (DZL), the German Center for Infection Research (DZIF), and the Center for Synthetic Microbiology (SYNMIKRO) Marburg, Hesse, Germany; Member of the Institute for Lung Health (ILH), Giessen, Hesse, Germany. Electronic address: [email protected].
³ Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany. Electronic address: [email protected].
⁴ Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany. Electronic address: [email protected].
⁵ Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, Marburg, Hesse, Germany; Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: [email protected].

PMID: 34022269
DOI: 10.1016/j.addr.2021.05.021

Abstract

Pneumonia is among the leading causes of morbidity and mortality worldwide. Due to constant evolution of respiratory bacteria and viruses, development of drug resistance and emerging pathogens, it constitutes a considerable health care threat. To enable development of novel strategies to control pneumonia, a better understanding of the complex mechanisms of interaction between host cells and infecting pathogens is vital. Here, we review the roles of host cell and bacterial-derived extracellular vesicles (EVs) in these interactions. We discuss clinical and experimental as well as pathogen-overarching and pathogen-specific evidence for common viral and bacterial elicitors of community- and hospital-acquired pneumonia. Finally, we highlight the potential of EVs for improved management of pneumonia patients and discuss the translational steps to be taken before they can be safely exploited as novel vaccines, biomarkers, or therapeutics in clinical practice.

Keywords: ARDS; Bacteria; Biomarker; Outer membrane vesicles; Sepsis; Therapeutics; Vaccine; Virus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Community-Acquired Infections / microbiology
Community-Acquired Infections / therapy
Drug Resistance, Microbial
Extracellular Vesicles / metabolism*
Healthcare-Associated Pneumonia / microbiology
Healthcare-Associated Pneumonia / therapy
Host Microbial Interactions
Humans
Pneumonia, Bacterial / microbiology*
Pneumonia, Bacterial / therapy
Pneumonia, Viral / microbiology*
Pneumonia, Viral / therapy