1 Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
2 Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
3 Department of Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh, Edinburgh, UK.
4 Adult Intensive Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
5 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
6 Kadoorie Centre for Critical Care Research, John Radcliffe Hospital, University of Oxford, Oxford, UK.