Regulation of nuclear mTORC1

Xin Zhou; Yanghao Zhong; Jin Zhang

doi:10.1080/23723556.2021.1896348

Regulation of nuclear mTORC1

Mol Cell Oncol. 2021 May 5;8(3):1896348. doi: 10.1080/23723556.2021.1896348. eCollection 2021.

Authors

Xin Zhou¹, Yanghao Zhong^{1

2}, Jin Zhang^{1

3

4}

Affiliations

¹ Department of Pharmacology, University of California, San Diego, CA, USA.
² Biomedical Sciences Graduate Program, University of California, San Diego, CA, USA.
³ Department of Bioengineering, University of California, San Diego, CA, USA.
⁴ Department of Chemistry & Biochemistry, University of California, San Diego, CA, USA.

Abstract

mTORC1 integrates diverse upstream signals to control cell growth and metabolism. We previously showed that mTORC1 activity is spatially compartmentalized to ensure its signaling specificity. In a recently published study, we demonstrated the existence of mTORC1 activity in the nucleus and identified a unique mode of its regulation in the nuclear compartment.

Keywords: RAPTOR; nuclear translocation; protein kinase; signaling specificity; spatial compartmentalization.

Abstract

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