The need for a refined understanding of CYP2D6 in second-generation antipsychotic outcomes in children and adolescents

Pharmacogenomics. 2021 Jun;22(8):447-450. doi: 10.2217/pgs-2021-0049. Epub 2021 May 25.

Abstract

Tweetable abstract High-quality studies examining the influence of CYP2D6 on the exposure and tolerability of antipsychotics in youth are needed to mitigate the limitations of prior studies.

Keywords: ADHD; CYP2D6; pediatric; psychiatric pharmacogenetics.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Antipsychotic Agents / therapeutic use*
  • Child
  • Cytochrome P-450 CYP2D6 / genetics*
  • Humans

Substances

  • Antipsychotic Agents
  • Cytochrome P-450 CYP2D6