Transcriptional signatures of human peripheral blood mononuclear cells can identify the risk of tuberculosis progression from latent infection among individuals with silicosis

Qiao-Ling Ruan; Qing-Luan Yang; Yi-Xin Gao; Jing Wu; Si-Ran Lin; Jing-Yu Zhou; Ling-Yun Shao; Sen Wang; Qian-Qian Liu; Yan Gao; Ning Jiang; Wen-Hong Zhang

doi:10.1080/22221751.2021.1915184

Transcriptional signatures of human peripheral blood mononuclear cells can identify the risk of tuberculosis progression from latent infection among individuals with silicosis

Emerg Microbes Infect. 2021 Dec;10(1):1536-1544. doi: 10.1080/22221751.2021.1915184.

Authors

Qiao-Ling Ruan^{1

2}, Qing-Luan Yang¹, Yi-Xin Gao¹, Jing Wu^{1

2}, Si-Ran Lin¹, Jing-Yu Zhou¹, Ling-Yun Shao^{1

2}, Sen Wang^{1

2}, Qian-Qian Liu¹, Yan Gao^{1

2}, Ning Jiang¹, Wen-Hong Zhang^{1

2

3}

Affiliations

¹ Department of Infectious Diseases, Huashan Hospital, School of Life Science, Fudan University, Shanghai, People's Republic of China.
² National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
³ Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Abstract

www.clinicaltrials.gov (NCT02430259).

Keywords: RNA sequencing; Tuberculosis; biomarker; interferon-gamma; latent tuberculosis infection; peripheral blood mononuclear cell.

Publication types

Randomized Controlled Trial

MeSH terms

Adolescent
Adult
Aged
Disease Progression
Female
Humans
Latent Infection
Leukocytes, Mononuclear / chemistry*
Leukocytes, Mononuclear / immunology
Male
Middle Aged
Risk Factors
Silicosis / complications*
Silicosis / genetics*
Silicosis / immunology
Tuberculosis / epidemiology
Tuberculosis / etiology
Tuberculosis / genetics*
Tuberculosis / pathology
Young Adult

Associated data

ClinicalTrials.gov/NCT02430259

Grants and funding

This work was supported by the Key Technologies Research and Development Program for Infectious Diseases of China[grant number 2017ZX10201302-004]; National Natural Science Foundation of China (NSFC) under grant number [81801975]; Shanghai Sailing Program under grant number [18YF1402800] and Key Laboratory Project of Shanghai Science and Technology Commission [grant numbers 20dz2210400]..