Endothelial Dysfunction as a Component of Severe Acute Respiratory Syndrome Coronavirus 2-Related Multisystem Inflammatory Syndrome in Children With Shock

Crit Care Med. 2021 Nov 1;49(11):e1151-e1156. doi: 10.1097/CCM.0000000000005093.

Abstract

Trial registration: NCT04420468.

Objectives: Severe acute respiratory syndrome coronavirus 2-related multisystem inflammatory syndrome in children is frequently associated with shock; endothelial involvement may be one of the underlying mechanisms. We sought to describe endothelial dysfunction during multisystem inflammatory syndrome in children with shock and then assess the relationship between the degree of endothelial involvement and the severity of shock.

Design: Observational study.

Setting: A PICU in a tertiary hospital.

Patients: Patients aged under 18 (n = 28) with severe acute respiratory syndrome coronavirus 2-related multisystem inflammatory syndrome in children and shock, according to the Centers for Disease Control and Prevention criteria.

Interventions: None.

Measurements and main results: Correlations between endothelial marker levels and shock severity were assessed using Spearman coefficient. The median (interquartile range) age was 9 years (7.5-11.2 yr). Sixteen children presented with cardiogenic and distributive shock, 10 presented with cardiogenic shock only, and two presented with distributive shock only. The median left ventricular ejection fraction, troponin level, and lactate level were, respectively, 40% (35-45%), 261 ng/mL (131-390 ng/mL), and 3.2 mmol/L (2-4.2 mmol/L). Twenty-five children received inotropes and/or vasopressors; the median Vasoactive and Inotropic Score was 8 (5-28). Plasma levels of angiopoietin-2 (6,426 pg/mL [2,814-11,836 pg/mL]), sE-selectin (130,405 pg/mL [92,987-192,499 pg/mL]), von Willebrand factor antigen (344% [288-378%]), and the angiopoietin-2/angiopoietin-1 ratio (1.111 [0.472-1.524]) were elevated and significantly correlated with the Vasoactive and Inotropic Score (r = 0.45, p = 0.016; r = 0.53, p = 0.04; r = 0.46, p = 0.013; and r = 0.46, p = 0.012, respectively).

Conclusions: Endothelial dysfunction is associated with severe acute respiratory syndrome coronavirus 2-related multisystem inflammatory syndrome in children with shock and may constitute one of the underlying mechanisms.

Publication types

  • Observational Study

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Angiopoietin-2 / blood
  • Biomarkers
  • C-Reactive Protein / analysis
  • COVID-19 / complications*
  • COVID-19 / pathology
  • COVID-19 Drug Treatment
  • Cardiotonic Agents / therapeutic use
  • Child
  • Female
  • Humans
  • Immunoglobulins / therapeutic use
  • Intensive Care Units, Pediatric
  • Interleukin-6 / blood
  • Lactic Acid / blood
  • Male
  • Respiration, Artificial
  • Retrospective Studies
  • SARS-CoV-2
  • Severity of Illness Index
  • Shock / pathology*
  • Shock, Cardiogenic / pathology
  • Systemic Inflammatory Response Syndrome / drug therapy
  • Systemic Inflammatory Response Syndrome / pathology*
  • Troponin / blood
  • Vasoconstrictor Agents / therapeutic use
  • Ventricular Function, Left

Substances

  • Adrenal Cortex Hormones
  • Angiopoietin-2
  • Biomarkers
  • Cardiotonic Agents
  • Immunoglobulins
  • Interleukin-6
  • Troponin
  • Vasoconstrictor Agents
  • Lactic Acid
  • C-Reactive Protein

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related

Associated data

  • ClinicalTrials.gov/NCT04420468