Neutralization Heterogeneity of UK and South African Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in BNT162b2-Vaccinated or Convalescent Coronavirus Disease 2019 (COVID-19) Healthcare Workers

Stéphane Marot; Isabelle Malet; Valentin Leducq; Basma Abdi; Elisa Teyssou; Cathia Soulie; Marc Wirden; Christophe Rodriguez; Slim Fourati; Jean-Michel Pawlotsky; David Boutolleau; Sonia Burrel; Vincent Calvez; Anne-Geneviève Marcelin; Aude Jary

doi:10.1093/cid/ciab492

Neutralization Heterogeneity of UK and South African Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in BNT162b2-Vaccinated or Convalescent Coronavirus Disease 2019 (COVID-19) Healthcare Workers

Clin Infect Dis. 2022 Mar 1;74(4):707-710. doi: 10.1093/cid/ciab492.

Authors

Stéphane Marot¹, Isabelle Malet¹, Valentin Leducq¹, Basma Abdi¹, Elisa Teyssou¹, Cathia Soulie¹, Marc Wirden¹, Christophe Rodriguez^{2

3}, Slim Fourati^{2

3}, Jean-Michel Pawlotsky^{2

3}, David Boutolleau¹, Sonia Burrel¹, Vincent Calvez¹, Anne-Geneviève Marcelin¹, Aude Jary¹

Affiliations

¹ Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Department of Virology, Paris, France.
² Department of Virology, Hôpitaux Universitaires Henri Mondor, AP-HP, Créteil, France.
³ Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Université Paris-Est, Créteil, France.

Abstract

There are concerns about neutralizing antibodies' (NAbs') potency against severe acute respiratory syndrome coronavirus 2 variants. Despite decreased NAb titers elicited by BNT162b2 vaccine against VOC202012/01 and 501Y.V2 strains, 28/29 healthcare workers (HCWs) had an NAb titer ≥1:10. In contrast, 6 months after coronavirus disease 2019 mild forms, only 9/15 (60%) of HCWs displayed detectable NAbs against 501Y.V2 strain.

Keywords: COVID-19; SARS-CoV-2 variants; neutralizing antibodies; vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
BNT162 Vaccine
COVID-19*
Health Personnel
Humans
SARS-CoV-2 / genetics
United Kingdom / epidemiology

Substances

Antibodies, Neutralizing
Antibodies, Viral
BNT162 Vaccine

Supplementary concepts

SARS-CoV-2 variants