Abstract
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19.
Keywords:
SARS-CoV-2; TPC channels; coronavirus; flavonoids; mammalian endolysosome; plant vacuole.
MeSH terms
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Antiviral Agents / pharmacology
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Antiviral Agents / therapeutic use
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Arabidopsis / metabolism
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COVID-19 / epidemiology
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COVID-19 / pathology
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COVID-19 / virology
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COVID-19 Drug Treatment*
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Calcium Channel Blockers / pharmacology*
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Calcium Channel Blockers / therapeutic use
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Calcium Channels / metabolism*
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Drug Evaluation, Preclinical
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Endosomes / drug effects
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Endosomes / metabolism
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Endosomes / virology
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Flavanones / pharmacology*
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Flavanones / therapeutic use
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Humans
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Lysosomes / drug effects
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Lysosomes / metabolism
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Lysosomes / virology
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Neoplasms / blood supply
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Neovascularization, Pathologic / drug therapy
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Neovascularization, Pathologic / pathology
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Pandemics / prevention & control
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SARS-CoV-2 / pathogenicity
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Vacuoles / metabolism
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Virus Internalization / drug effects
Substances
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Antineoplastic Agents
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Antiviral Agents
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Calcium Channel Blockers
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Calcium Channels
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Flavanones
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naringenin