A case of metastatic renal cell carcinoma with concomitant Castleman's disease treated with immunotherapy

Taja Lozar; Matthew J Brunner; Sujal I Shah; Christos E Kyriakopoulos; Hamid Emamekhoo

doi:10.1016/j.eucr.2021.101720

A case of metastatic renal cell carcinoma with concomitant Castleman's disease treated with immunotherapy

Urol Case Rep. 2021 May 17:38:101720. doi: 10.1016/j.eucr.2021.101720. eCollection 2021 Sep.

Authors

Taja Lozar^{1

2}, Matthew J Brunner³, Sujal I Shah^{4

5}, Christos E Kyriakopoulos^{3

6}, Hamid Emamekhoo^{3

6}

Affiliations

¹ Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
² McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
³ University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
⁴ Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
⁵ Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁶ University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Abstract

Castleman's disease (CD) is an uncommon lymphoproliferative process that can present concurrent to other solid organ malignancy, especially in selected populations. Concomitant CD and renal cell carcinoma (RCC) are challenging in terms of diagnosis and treatment. Assessment of CD involvement is a crucial step in selecting the optimal treatment strategy. Here we report a case of metastatic RCC and concurrent CD treated with surgery and immunotherapy.

Keywords: Castleman's disease; Immunotherapy; RCC.

Publication types

Case Reports