Immune responses and therapeutic challenges in paediatric patients with new-onset acute myeloid leukaemia and concomitant COVID-19

Pratik A Patel; Stacey A Lapp; Gabrielle Grubbs; Venkata V Edara; Christina A Rostad; Claire L Stokes; Melinda G Pauly; Evan J Anderson; Anne Piantadosi; Mehul S Suthar; Surender Khurana; Himalee S Sabnis

doi:10.1111/bjh.17517

Immune responses and therapeutic challenges in paediatric patients with new-onset acute myeloid leukaemia and concomitant COVID-19

Br J Haematol. 2021 Aug;194(3):549-553. doi: 10.1111/bjh.17517. Epub 2021 Jun 7.

Authors

Pratik A Patel^{1

2}, Stacey A Lapp^{3

4}, Gabrielle Grubbs⁵, Venkata V Edara^{3

4

6

7}, Christina A Rostad^{3

4}, Claire L Stokes^{1

2}, Melinda G Pauly^{1

2}, Evan J Anderson^{3

4

8}, Anne Piantadosi^{8

9}, Mehul S Suthar^{3

4

6

7}, Surender Khurana⁵, Himalee S Sabnis^{1

2}

Affiliations

¹ Department of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplantation, Emory University School of Medicine, Atlanta, GA, USA.
² Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.
³ Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
⁴ Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Atlanta, GA, USA.
⁵ Division of Viral Products, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, USA.
⁶ Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
⁷ Yerkes Primate Center, Emory University School of Medicine, Atlanta, GA, USA.
⁸ Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
⁹ Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.

No abstract available

Keywords: AML; COVID-19; children; induction chemotherapy; serology.

Publication types

Case Reports
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Monophosphate / analogs & derivatives
Adenosine Monophosphate / therapeutic use
Adolescent
Alanine / analogs & derivatives
Alanine / therapeutic use
Antimalarials / therapeutic use
Antineoplastic Agents / therapeutic use
Antiviral Agents / therapeutic use
COVID-19 / complications*
COVID-19 / diagnosis
COVID-19 / immunology
COVID-19 Drug Treatment
Disease Management
Humans
Hydroxychloroquine / therapeutic use
Hydroxyurea / therapeutic use
Leukemia, Myeloid, Acute / complications*
Leukemia, Myeloid, Acute / drug therapy
Leukemia, Myeloid, Acute / immunology
Male
SARS-CoV-2 / drug effects
SARS-CoV-2 / immunology
SARS-CoV-2 / isolation & purification
Young Adult

Substances

Antimalarials
Antineoplastic Agents
Antiviral Agents
remdesivir
Adenosine Monophosphate
Hydroxychloroquine
Alanine
Hydroxyurea

Publication types

MeSH terms

Substances

Grants and funding