Phospholipid-coated targeted microbubbles for ultrasound molecular imaging and therapy

Curr Opin Chem Biol. 2021 Aug:63:171-179. doi: 10.1016/j.cbpa.2021.04.013. Epub 2021 Jun 5.

Abstract

Phospholipid-coated microbubbles are ultrasound contrast agents that, when functionalized, adhere to specific biomarkers on cells. In this concise review, we highlight recent developments in strategies for targeting the microbubbles and their use for ultrasound molecular imaging (UMI) and therapy. Recently developed novel targeting strategies include magnetic functionalization, triple targeting, and the use of several new ligands. UMI is a powerful technique for studying disease progression, diagnostic imaging, and monitoring of therapeutic responses. Targeted microbubbles (tMBs) have been used for the treatment of cardiovascular diseases and cancer, with therapeutics either coadministered or loaded onto the tMBs. Regardless of which disease was treated, the use of tMBs always resulted in a better therapeutic outcome than non-tMBs when compared in vitro or in vivo.

Keywords: Biomarker; Ligand; Targeted drug delivery; Targeted microbubble; Ultrasound; Ultrasound molecular imaging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / diagnostic imaging*
  • Cardiovascular Diseases / drug therapy*
  • Contrast Media / chemistry
  • Drug Carriers / administration & dosage
  • Drug Carriers / chemistry
  • Drug Therapy, Combination
  • Humans
  • Microbubbles
  • Molecular Imaging / methods
  • Molecular Targeted Therapy
  • Neoplasms / diagnostic imaging*
  • Neoplasms / drug therapy*
  • Phospholipids / chemistry*
  • Treatment Outcome
  • Ultrasonography

Substances

  • Contrast Media
  • Drug Carriers
  • Phospholipids