SARS-CoV-2 reinfection with a virus harboring mutation in the Spike and the Nucleocapsid proteins in Panama

Yamilka Díaz; Anyuri Ortiz; Adriana Weeden; Daniel Castillo; Claudia González; Brechla Moreno; Mabel Martínez-Montero; Marlene Castillo; Grettel Vasquez; Lisseth Sáenz; Danilo Franco; Yaneth Pitti; Oris Chavarria; Jessica Gondola; Ambar M Moreno; Leyda Ábrego; Davis Beltrán; Ilka Guerra; Jim Chang; Zumara Chaverra; Isela Guerrero; Alejandra Valoy; Melissa Gaitán; Dimelza Araúz; Ernesto Morán; Maria Chen-Germán; Elimelec Valdespino; Rita Rodríguez; Rita Corrales; Roderick Chen-Camaño; Juan Miguel Pascale; Alexander A Martínez; Sandra López-Vergès; Gorgas COVID19 Team

doi:10.1016/j.ijid.2021.06.004

SARS-CoV-2 reinfection with a virus harboring mutation in the Spike and the Nucleocapsid proteins in Panama

Int J Infect Dis. 2021 Jul:108:588-591. doi: 10.1016/j.ijid.2021.06.004. Epub 2021 Jun 6.

Authors

Yamilka Díaz¹, Anyuri Ortiz², Adriana Weeden³, Daniel Castillo¹, Claudia González⁴, Brechla Moreno¹, Mabel Martínez-Montero⁵, Marlene Castillo¹, Grettel Vasquez¹, Lisseth Sáenz¹, Danilo Franco¹, Yaneth Pitti¹, Oris Chavarria⁴, Jessica Gondola⁴, Ambar M Moreno⁴, Leyda Ábrego¹, Davis Beltrán¹, Ilka Guerra¹, Jim Chang¹, Zumara Chaverra¹, Isela Guerrero¹, Alejandra Valoy¹, Melissa Gaitán¹, Dimelza Araúz¹, Ernesto Morán¹, Maria Chen-Germán¹, Elimelec Valdespino¹, Rita Rodríguez¹, Rita Corrales¹, Roderick Chen-Camaño¹, Juan Miguel Pascale³, Alexander A Martínez⁶, Sandra López-Vergès⁷; Gorgas COVID19 Team

Affiliations

¹ Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama.
² Department of Occupational Health, Gorgas Memorial Institute of Health Studies, Panama.
³ Unit of Diagnosis, Clinical Research and Tropical Medicine, Gorgas Memorial Institute of Health Studies, Panama.
⁴ Department of Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Panama.
⁵ Immunovirology Division, Public Health Reference Central Laboratory, Gorgas Memorial Institute of Health Studies, Panama.
⁶ Department of Genomic and Proteomic, Gorgas Memorial Institute of Health Studies, Panama. Electronic address: [email protected].
⁷ Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama. Electronic address: [email protected].

Abstract

We report a case of reinfection by SARS-CoV-2 with the second virus harboring amino acid changes in the Spike protein (141-143del, D215A, ins215AGY, L452R, D614G), orf1a, helicase, orf3a, and Nucleocapside. The virus associated with the reinfection, from an endemic lineage containing the S:L452R immune escape mutation, was circulating in Panama at the time.

Keywords: COVID-19; Mutation; Panama; Reinfection; SARS-CoV-2.

Publication types

Case Reports

MeSH terms

COVID-19*
Humans
Mutation
Nucleocapsid Proteins
Reinfection
SARS-CoV-2*
Spike Glycoprotein, Coronavirus / genetics

Substances

Nucleocapsid Proteins
Spike Glycoprotein, Coronavirus