Five cases of acanthoma fissuratum observed in the last years are reported. These lesions, located along the retroauricular fold and on the nasal bridge, are caused by ill-fitting eyeglasses. Clinically, acanthoma fissuratum is often mistaken for a basal cell epithelioma. The definitive diagnosis can be confirmed by characteristic histologic features in association with clinical and anamnestic data. Acanthoma fissuratum merits recognition as a distinctive lesion of importance for dermatologists and surgeons.