Clinical management of patients with thymic epithelial tumors: the recommendations endorsed by the Italian Association of Medical Oncology (AIOM)

F Conforti; M Marino; V Vitolo; L Spaggiari; R Mantegazza; P Zucali; E Ruffini; L di Tommaso; G Pelosi; M Barberis; I Petrini; G Palmieri; G Pasello; G Galli; R Berardi; M Garassino; P Filosso; M Alloisio; M Scorsetti; R Orecchia; L Pala; L Abatedaga; S Cinieri; T De Pas

doi:10.1016/j.esmoop.2021.100188

Clinical management of patients with thymic epithelial tumors: the recommendations endorsed by the Italian Association of Medical Oncology (AIOM)

ESMO Open. 2021 Aug;6(4):100188. doi: 10.1016/j.esmoop.2021.100188. Epub 2021 Jun 8.

Authors

F Conforti¹, M Marino², V Vitolo³, L Spaggiari⁴, R Mantegazza⁵, P Zucali⁶, E Ruffini⁷, L di Tommaso⁸, G Pelosi⁹, M Barberis¹⁰, I Petrini¹¹, G Palmieri¹², G Pasello¹³, G Galli¹⁴, R Berardi¹⁵, M Garassino¹⁴, P Filosso¹⁶, M Alloisio¹⁷, M Scorsetti¹⁸, R Orecchia¹⁹, L Pala²⁰, L Abatedaga²¹, S Cinieri²², T De Pas²⁰

Affiliations

¹ Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, Istituto Europeo di Oncologia, IRCCS, Milan, Italy. Electronic address: [email protected].
² Department of Pathological Anatomy, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.
³ National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
⁴ Department of Thoracic Surgery, IRCCS European Institute of Oncology, Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
⁵ Department of Neuroimmunology and Neuromuscular Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
⁶ Department of Medical Oncology and Hematology, Humanitas Clinical and Research Center-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, Italy.
⁷ Department of Thoracic Surgery, San Giovanni Battista Hospital, University of Torino, Torino, Italy.
⁸ Department of Pathology, Humanitas Clinical and Research Center, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Italy.
⁹ Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
¹⁰ Division of Pathology and Laboratory Medicine, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
¹¹ Department of Critical Area and Surgical, Medical and Molecular Pathology, University of Pisa, Pisa, Italy.
¹² Scientific Direction, Department of Clinical Medicine and Surgery, Rare Tumors Reference Center, University Federico II, Naples, Italy.
¹³ Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
¹⁴ Thoracic Oncology, Medical Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
¹⁵ Medical Oncology Unit, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I-GM Lancisi-G Salesi, Ancona, Italy.
¹⁶ Thoracic Surgery Unit, University of Torino, Torino, Italy.
¹⁷ Department of Neurosurgery, Humanitas Clinical and Research Center-IRCSS, Rozzano, Italy.
¹⁸ Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center-IRCSS, Rozzano, Italy.
¹⁹ Scientific Direction, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
²⁰ Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.
²¹ Associazione TU.TO.R. Tumori Toracici Rari, Milan, Italy.
²² Medical Oncology Unit, Antonio Perrino Hospital, Brindisi, Italy.

Abstract

The Italian Association of Medical Oncology recommendations on thymic epithelial tumors, which have been drawn up for the first time in 2020 through an evidence-based approach, report indications on all the main aspects of clinical management of this group of rare diseases, from diagnosis and staging, to new available systemic treatments, such as targeted therapies and immunotherapies. A summary of key recommendations is presented here and complete recommendations are reported as Supplementary Materials, available at https://doi.org/10.1016/j.esmoop.2021.100188.

Keywords: AIOM; recommendations; thymic epithelial tumors.

Publication types

Review

MeSH terms

Humans
Italy
Medical Oncology
Neoplasms, Glandular and Epithelial* / diagnosis
Neoplasms, Glandular and Epithelial* / therapy
Thymus Neoplasms* / diagnosis
Thymus Neoplasms* / therapy