Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Yueying Zhou; Xiaonan Xin; Lichao Wang; Binsheng Wang; Li Chen; Ousheng Liu; David W Rowe; Ming Xu

doi:10.1038/s41536-021-00145-z

Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

NPJ Regen Med. 2021 Jun 11;6(1):34. doi: 10.1038/s41536-021-00145-z.

Authors

Yueying Zhou^{1

2

3}, Xiaonan Xin³, Lichao Wang^{2

4}, Binsheng Wang^{2

4}, Li Chen³, Ousheng Liu¹, David W Rowe⁵, Ming Xu^{6

7}

Affiliations

¹ Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China.
² UConn Center on Aging, Farmington, CT, USA.
³ Center for Regenerative Medicine and Skeletal Development, Farmington, CT, USA.
⁴ Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.
⁵ Center for Regenerative Medicine and Skeletal Development, Farmington, CT, USA. [email protected].
⁶ UConn Center on Aging, Farmington, CT, USA. [email protected].
⁷ Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA. [email protected].

Abstract

The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.

Abstract

Grants and funding