The role of single-cell sequencing in studying tumour evolution

Maximilian Mossner; Ann-Marie C Baker; Trevor A Graham

doi:10.12703/r/10-49

The role of single-cell sequencing in studying tumour evolution

Fac Rev. 2021 May 26:10:49. doi: 10.12703/r/10-49. eCollection 2021.

Authors

Maximilian Mossner¹, Ann-Marie C Baker¹, Trevor A Graham¹

Affiliation

¹ Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

Abstract

Tumour evolution is a complex interplay between the acquisition of somatic (epi)genomic changes in tumour cells and the phenotypic consequences they cause, all in the context of a changing microenvironment. Single-cell sequencing offers a window into this dynamic process at the ultimate resolution of individual cells. In this review, we discuss the transformative insight offered by single-cell sequencing technologies for understanding tumour evolution.

Keywords: scDNA-Seq; scRNA-Seq; single cell sequencing; tumour evolution.

Publication types

Review

Abstract

Publication types

Grants and funding