ASSESSMENT OF PATIENT'S RADIATION EXPOSURES RESULTED FROM PET/CT 18F-FCH AND 68GA-PSMA PROCEDURES

H Salah; H I Al-Mohammed; F H Mayhoub; A Sulieman; M Alkhorayef; Fouad A Abolaban; Mayeen Uddin Khandaker; D A Bradley

doi:10.1093/rpd/ncab077

ASSESSMENT OF PATIENT'S RADIATION EXPOSURES RESULTED FROM PET/CT 18F-FCH AND 68GA-PSMA PROCEDURES

Radiat Prot Dosimetry. 2021 Oct 12;195(3-4):349-354. doi: 10.1093/rpd/ncab077.

Authors

H Salah^{1

2}, H I Al-Mohammed³, F H Mayhoub⁴, A Sulieman⁵, M Alkhorayef^{6

7}, Fouad A Abolaban⁸, Mayeen Uddin Khandaker⁹, D A Bradley^{7

9}

Affiliations

¹ INAYA Medical Collage, Nuclear Medicine Department, P.O. Box 271880, Riyadh 11352, Saudi Arabia.
² Basic Science Department, College of Medical Radiologic Science, Sudan University of Science and Technology, P.O.Box 1908, Khartoum 11111, Sudan.
³ Department of Radiological Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671 Saudi Arabia.
⁴ Department of Biomedical Physics, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
⁵ Prince Sattam Bin Abdulaziz University, College of Applied Medical Sciences, Radiology and Medical Imaging Department, P.O.Box 422, Alkharj 11942, Saudi Arabia.
⁶ Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, P.O.Box 10219, Riyadh 11433, Saudi Arabia.
⁷ Centre for Nuclear and Radiation Physics, Department of Physics, University of Surrey, Guildford GU2 7XH, UK.
⁸ Nuclear Engineering Department, Faculty of Engineering, King Abdulaziz University, P. O. Box 80221, Jeddah 21589, Saudi Arabia.
⁹ Centre for Biomedical Physics, School of Healthcare and Medical Sciences, Sunway University, 47500 46150 PJ, Bandar, No. 5, Jalan Universiti, Sunway, Selangor Darul Ehsan, Malaysia.

PMID: 34144608
DOI: 10.1093/rpd/ncab077

Abstract

This study has sought to evaluate patient exposures during the course of particular diagnostic positron emission tomography and computed tomography (PET/CT) techniques. A total of 73 patients were examined using two types of radiopharmaceutical: 18F-fluorocholine (FCH, 48 patients) and 68Ga-prostate-specific membrane antigen (PSMA, 25 patients). The mean and range of administered activity (AA) in MBq, and effective dose (mSv) for FCH were 314.4 ± 61.6 (462.5-216.8) and 5.9 ± 1.2 (8.8-4.11), respectively. Quoted in the same set of units, the mean and range of AA and effective dose for 68Ga-PSMA were 179.3 ± 92.3 (603.1-115.1) and 17.9 ± 9.2 (60.3-11.5). Patient effective doses from 18F-FCH being a factor of two greater than the dose resulting from 68Ga-PSMA PET/CT procedures. CT accounts for some 84 and 23% for 18F-FCH and 68Ga-PSMA procedures, accordingly CT acquisition parameter optimization is recommended. Patient doses have been found to be slightly greater than previous studies.

MeSH terms

Choline / analogs & derivatives
Gallium Isotopes
Gallium Radioisotopes
Humans
Male
Positron Emission Tomography Computed Tomography
Prostatic Neoplasms* / diagnostic imaging
Prostatic Neoplasms* / radiotherapy
Radiation Exposure*

Substances

Gallium Isotopes
Gallium Radioisotopes
gallium 68 PSMA-11
fluorocholine
Choline