5-Aminolevulinate synthase is at 3p21 and thus not the primary defect in X-linked sideroblastic anemia

G R Sutherland; E Baker; D F Callen; V J Hyland; B K May; M J Bawden; H M Healy; I A Borthwick

5-Aminolevulinate synthase is at 3p21 and thus not the primary defect in X-linked sideroblastic anemia

Am J Hum Genet. 1988 Sep;43(3):331-5.

Authors

G R Sutherland¹, E Baker, D F Callen, V J Hyland, B K May, M J Bawden, H M Healy, I A Borthwick

Affiliation

¹ Cytogenetics Unit, Adelaide Children's Hospital, Australia.

PMID: 3414687
PMCID: PMC1715374

Abstract

The gene for 5-aminolevulinate synthase (ALAS) has been mapped to 3pter-3q13.2 by Southern blot hybridization analysis of a mouse/human hybrid cell panel. In situ hybridization maps the gene to 3p21, distal to the common fragile site at 3p14.2 (FRA3B). The mapping of this gene to an autosome makes it improbable that it is the site of the primary defect in X-linked sideroblastic anemia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5-Aminolevulinate Synthetase / genetics*
Anemia, Sideroblastic / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 3*
Cloning, Molecular
Humans
Nucleic Acid Hybridization

Substances

5-Aminolevulinate Synthetase