Methods for Suppressing Hydrogen Sulfide in Biological Systems

Significance: Hydrogen sulfide (H₂S) plays critical roles in redox biology, and its regulatory effects are tightly controlled by its cellular location and concentration. The imbalance of H₂S is believed to contribute to some pathological processes. Recent Advances: Downregulation of H₂S requires chemical tools such as inhibitors of H₂S-producing enzymes and H₂S scavengers. Recent efforts have discovered some promising inhibitors and scavengers. These advances pave the road toward better understanding of the functions of H₂S. Critical Issues: Precise H₂S downregulation is challenging. The potency and specificity of current inhibitors are still far from ideal. H₂S-producing enzymes are involved in complex sulfur metabolic pathways and ubiquitously present in biological matrices. The inhibition of these enzymes can cause unwanted side effects. H₂S scavengers allow targeted H₂S clearance, but their options are still limited. In addition, the scavenging process often results in biologically active by-products. Future Directions: Further development of potent and specific inhibitors for H₂S-producing enzymes is needed. Scavengers that can rapidly and selectively remove H₂S while generating biocompatible by-products are needed. Potential therapeutic applications of scavengers and inhibitors are worth exploring. Antioxid. Redox Signal. 36, 294-308.